Dr Edinam Agbenu, la responsable de la sécurité et de la qualité des vaccins au sein du Bureau régional de l’Organisation mondiale de la Santé pour l’Afrique, explique à la BBC ce qu’est l’ARN messager (acide ribonucléique messager) et son utilisation dans les vaccins, notamment ceux contre le Covid-19.
La spécialiste togolaise s’est entretenue avec Benoît Alméras de l’émission Question Santé.
Qu’est-ce que l’ARN messager en termes simples ?
Les organismes vivants sont faits de cellules et de molécules. Et donc, parmi les molécules dont nous sommes constitués, il y a ce qu’on appelle l’ARN messager. Nous connaissons tous les protéines, par exemple c’est le constituant majeur des viandes. Pour fabriquer les protéines, il faut que l’information soit lue à partir du noyau des cellules. Dans le noyau, nous avons les chromosomes, l’ADN. Et pour que le noyau s’exprime en protéines, il y a une étape intermédiaire qu’on appelle ARN messager et qui, en fait est comme une photocopie. Vous avez un livre, vous voulez le scanner, vous scannez une page dont vous avez besoin. Cette page que vous avez scannée et que vous pouvez envoyer plus loin, elle s’appelle ARN messager.
Alors, de quand date la première utilisation de l’ARN messager pour un usage vaccinal ?
Les ARN messagers sont en étude depuis les années 90. L’intention première était justement d’améliorer l’arsenal thérapeutique dont les vaccins. Et ça a commencé dans les années 90. Par la suite, au fil des ans, il a été question d’améliorer la stabilité de cet ARN messager parce que vous savez, lorsqu’on administre une substance à un organisme vivant, la substance va être prise en charge et détruite rapidement. Mais pour que l’ARNm puisse effectivement mettre en œuvre la réponse immunitaire, donc la vaccination, il faut qu’il passe un peu plus de temps, au moins qu’il arrive dans le cytoplasme des cellules ; s’il est détruit trop rapidement, ce n’est pas bon. Donc, il fallu trouver les moyens de stabiliser un peu tout ça. Cela a pris un peu de temps, mais avec la pandémie Covid, cette étude qui était destinée à servir à des vaccins contre le cancer etc, les chercheurs se sont mis ensemble et ont rapidement fait avancer la production des vaccins à ARN messager.
En quoi la pandémie de Covid a facilité le développement de cette technologie ?
Bon, parce que la pandémie à Covid-19 nous a tous un peu pris de court et il fallait trouver une réponse rapide. La technologie qui permettait de produire une quantité suffisante de vaccins pour arrêter le désastre était quand même que cette technologie ARN messager marche. Et il était question d’abord d’isoler, quel antigène peut être utilisé. L’antigène, c’est ce à quoi notre organisme va reconnaitre le virus comme un agresseur pour pouvoir développer la réponse de défense, la réponse immunitaire. Et le virus est fait de plusieurs antigènes. Il faut trouver le bon antigène que l’on va utiliser pour entrainer l’organisme à se défendre contre le virus. Cela ne dépend pas de l’ARN messager. Mais une fois que ça a été sélectionné, comment fabriquer le vaccin qui répond à cet antigène en très grande quantité dans un temps record. Le partage d’informations et l’existence d’une étude déjà avancée sur les ARN messagers a permis juste de saisir cette opportunité.
Les vaccins ARN messagers des sociétés Pfeizer–BioNtech et Moderna sont réputés plus efficaces contre le coronavirus, mais concrètement, quels sont les avantages de ces ARN messagers comparés à d’autres vaccins qui sont basés sur d’autres technologies plus anciennes ?
Par rapport aux vaccins traditionnels, je l’appellerais un transfert de technologie du laboratoire à l’organisme. Traditionnellement, vous avez un virus. On peut prendre le virus vivant et l’injecter. L’organisme va se défendre contre ce virus qui est affaibli. On appelle ça, virus atténué. Mais le risque avec un virus atténué est qu’il y ait une réversion et un retour à la forme virulente. L’atténuation, quand même, a permis d’obtenir des vaccins contre la fièvre jaune, contre la rougeole, etc. On a une autre technologie qui permet d’inactiver, donc de tuer le virus et de l’envoyer. La grande limite d’un virus qui est tué, c’est qu’il ne circule pas beaucoup dans l’organisme. Donc, il passe très vite, un peu trop vite et on n’a pas une réponse qui dure dans le temps.
Dans le cadre de la technologie qui utilise l’ARN messager, on fait un transfert de technologie. Donc, une fois qu’on a retrouvé la protéine du virus qui va donner une bonne réponse, cet ARN messager peut maintenant produire cette protéine depuis l’intérieur de l’organisme en quantités suffisantes pour générer la réponse immunitaire. Il faut savoir que si on le fait, c’est un peu comme si autrefois en Afrique on achetait des motos déjà faites en Chine, aujourd’hui, on fait venir les pièces détachées et on les fabrique ici. Et on sait qu’il y a déjà certaines industries qui ont juste le modèle et qui reproduisent. Donc, en fait c’est juste un transfert de technologie, de l’industrie à l’organisme, l’ARN messager ; ça permet de diminuer la quantité qu’on administre à la personne ; ça permet d’obtenir une stimulation du système immunitaire plus longtemps. Et il faut savoir qu’il y a une amplification de la quantité de protéines qui est finalement présentée à l’organisme. Et ça permet aussi pour l’approvisionnement en vaccins de réduire le temps de production pour pouvoir suppléer aux besoins de la planète.
On a l’impression, à vous entendre, qu’il s’agit quasiment de vaccins miracles, en fait, qui sont plus rapides, qui sont potentiellement aussi plus efficaces, mais y-a-t-il des désavantages, des risques, voire des dangers à utiliser des vaccins à ARN messager ?
Tout produit étranger, tout corps étranger qu’on administre à un organisme est reconnu comme agresseur et l’organisme va lutter contre cela et cela va se manifester cliniquement par des signes que l’on aura. On aura la fièvre, on aura des maux de tête, etc. Certains d’entre eux étant graves. Et sur les données actuelles, les vaccins à ARN messagers utilisés jusqu’à présent se sont suivis de dix, voire cent fois moins d’effets indésirables que les autres vaccins.
Alors, la grande question que les gens se posent par rapport aux vaccins ARN messagers, c’est que ce vaccin modifie le matériel génétique de l’individu. Il faut savoir que ce n’est pas envisageable. Et pourquoi est-ce qu’il n’est pas envisageable que l’ARN messager s’intègre dans le chromosome, c’est que le chromosome se trouve dans le noyau. L’ARN messager, il a une voie unidirectionnelle, il réside dans le cytoplasme. C’est un peu comme dans une maison, vous avez la membrane de la cellule, on peut considérer que c’est la clôture. Vous avez la cour, vous considérez que c’est le cytoplasme et vous avez le noyau, c’est un peu l’espace vital à l’intérieur. Donc, l’ARN messager reste dans le cytoplasme alors que le chromosome qui est en fait l’identité de l’individu se trouve dans le noyau.
Les vaccins ARN messager ont commencé à être développés bien avant la pandémie de Covid, mais je voudrais vous proposer un exercice de prospective. Quels sont les futurs développements pour ces vaccins ARN messager ?
La recherche sur les ARN messagers continue et un des grands objectifs, c’est d’améliorer la stabilité de cet ARN messager une fois qu’il est administré parce qu’il faudrait bien qu’il produise la protéine pour que cela donne la réponse immunitaire. Et un autre développement, c’est que tous les vaccins pour lesquels la production est un peu difficile, en termes de délai de production et autres, la recherche va continuer pour voir dans quelles mesures les vaccins ARN messagers pourraient être produits pour ça et un grand intérêt existe déjà pour les vaccins contre les cancers et certaines autres maladies évitables par la vaccination.
I do consider all of the ideas you’ve introduced on your post. They’re very convincing and can definitely work. Still, the posts are very brief for newbies. May just you please prolong them a little from next time? Thank you for the post.
Throughout this awesome design of things you actually receive a B- with regard to effort. Where you actually lost us ended up being on your details. As it is said, the devil is in the details… And that couldn’t be much more correct in this article. Having said that, allow me say to you just what exactly did work. Your writing is certainly really persuasive which is probably the reason why I am making the effort to opine. I do not really make it a regular habit of doing that. Next, whilst I can notice a leaps in reason you come up with, I am not certain of exactly how you seem to connect the ideas which inturn produce your final result. For right now I shall subscribe to your issue however trust in the near future you connect your dots much better.
he blog was how do i say it… relevant, finally something that helped me. Thanks
I am now not positive where you’re getting your info, but good topic. I must spend a while studying more or working out more. Thanks for fantastic info I used to be looking for this information for my mission.
Hello, i think that i saw you visited my website so i came to “return the favor”.I am trying to find things to improve my site!I suppose its ok to use some of your ideas!!
hi!,I like your writing so much! share we communicate more about your article on AOL? I require an expert on this area to solve my problem. May be that’s you! Looking forward to see you.
Amazing blog! Is your theme custom made or did you download it from somewhere? A theme like yours with a few simple tweeks would really make my blog stand out. Please let me know where you got your design. Thank you
I will right away snatch your rss as I can not in finding your e-mail subscription hyperlink or e-newsletter service. Do you have any? Please allow me understand so that I could subscribe. Thanks.
I like this post, enjoyed this one appreciate it for posting.
I was just searching for this info for some time. After 6 hours of continuous Googleing, finally I got it in your site. I wonder what is the lack of Google strategy that don’t rank this type of informative websites in top of the list. Usually the top web sites are full of garbage.
What’s Going down i am new to this, I stumbled upon this I’ve discovered It positively helpful and it has aided me out loads. I hope to contribute & aid different customers like its aided me. Great job.
I like this blog its a master peace ! Glad I discovered this on google .
Wow! Thank you! I always wanted to write on my blog something like that. Can I implement a portion of your post to my blog?
Hello there, just became alert to your blog through Google, and found that it is really informative. I am going to watch out for brussels. I’ll be grateful if you continue this in future. A lot of people will be benefited from your writing. Cheers!
Interesting blog! Is your theme custom made or did you download it from somewhere? A theme like yours with a few simple tweeks would really make my blog stand out. Please let me know where you got your design. Bless you
I’ve recently started a website, the information you provide on this website has helped me tremendously. Thank you for all of your time & work. “Money is power, freedom, a cushion, the root of al evil, the sum of all blessings.” by Carl Sandburg.
It’s hard to find knowledgeable people on this topic, but you sound like you know what you’re talking about! Thanks
I am really enjoying the theme/design of your site. Do you ever run into any browser compatibility problems? A small number of my blog audience have complained about my website not operating correctly in Explorer but looks great in Firefox. Do you have any recommendations to help fix this issue?
Hey very nice website!! Man .. Beautiful .. Amazing .. I will bookmark your site and take the feeds also…I’m happy to find numerous useful info here in the post, we need develop more techniques in this regard, thanks for sharing. . . . . .
Hi , I do believe this is an excellent blog. I stumbled upon it on Yahoo , i will come back once again. Money and freedom is the best way to change, may you be rich and help other people.
Hello just wanted to give you a quick heads up and let you know a few of the images aren’t loading correctly. I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and both show the same results.
I really prize your piece of work, Great post.
I every time spent my half an hour to read this web site’s articles everyday along
with a cup of coffee.
Terrific paintings! That is the kind of info that should be shared around the net. Disgrace on Google for not positioning this submit higher! Come on over and visit my web site . Thank you =)
Really instructive and superb complex body part of subject material, now that’s user friendly (:.
Just wanna comment on few general things, The website design and style is perfect, the articles is really excellent : D.
Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point. You definitely know what youre talking about, why waste your intelligence on just posting videos to your site when you could be giving us something enlightening to read?
I like what you guys are up too. Such clever work and coverage! Keep up the terrific works guys I’ve incorporated you guys to my blogroll.
Hi, i feel that i saw you visited my web site so i got here to go back the want?.I am trying to in finding things to improve my site!I guess its good enough to use some of your concepts!!
If you are going for most excellent contents like me, only go to see this web site everyday because it offers quality contents, thanks
справки москва
Excellent post. I was checking continuously this blog and I am impressed! Very useful information specially the last part 🙂 I care for such info a lot. I was seeking this particular info for a long time. Thank you and good luck.
Hi! I just wanted to ask if you ever have any problems with hackers? My last blog (wordpress) was hacked and I ended up losing months of hard work due to no data backup. Do you have any solutions to prevent hackers?
Hi there! Do you use Twitter? I’d like to follow you if that would be ok. I’m definitely enjoying your blog and look forward to new updates.
I read this article fully about the comparison of newest and preceding technologies, it’s remarkable article.
You ought to take part in a contest for one of the finest blogs on the internet. I most certainly will recommend this site!
My spouse and I stumbled over here different website and thought I might check things out. I like what I see so now i’m following you. Look forward to checking out your web page for a second time.
I am really happy to read this webpage posts which consists of plenty of helpful information, thanks for providing these information.
Please let me know if you’re looking for a author for your site. You have some really great posts and I believe I would be a good asset. If you ever want to take some of the load off, I’d really like to write some material for your blog in exchange for a link back to mine. Please blast me an e-mail if interested. Regards!
Hi, i read your blog occasionally and i own a similar one and i was just wondering if you get a lot of spam feedback? If so how do you stop it, any plugin or anything you can suggest? I get so much lately it’s driving me insane so any assistance is very much appreciated.
Hi, I do believe this is an excellent blog. I stumbledupon it 😉 I will return once again since I book-marked it. Money and freedom is the best way to change, may you be rich and continue to help other people.
First off I want to say awesome blog! I had a quick question that I’d like to ask if you don’t mind. I was curious to know how you center yourself and clear your mind before writing. I have had trouble clearing my mind in getting my thoughts out. I do enjoy writing but it just seems like the first 10 to 15 minutes are generally wasted just trying to figure out how to begin. Any ideas or tips? Thanks!
Can I simply say what a relief to discover an individual who actually knows what they’re talking about on the web. You certainly know how to bring an issue to light and make it important. More people have to read this and understand this side of the story. I was surprised that you aren’t more popular because you certainly have the gift.
I was wondering if you ever considered changing the page layout of your site? Its very well written; I love what youve got to say. But maybe you could a little more in the way of content so people could connect with it better. Youve got an awful lot of text for only having one or two images. Maybe you could space it out better?
Hey there! Would you mind if I share your blog with my zynga group? There’s a lot of people that I think would really enjoy your content. Please let me know. Cheers
I read this piece of writing fully about the comparison of most recent and preceding technologies, it’s remarkable article.
Incredible! This blog looks exactly like my old one! It’s on a entirely different topic but it has pretty much the same layout and design. Great choice of colors!
Thanks for one’s marvelous posting! I seriously enjoyed reading it, you may be a great author.I will make sure to bookmark your blog and definitely will come back in the foreseeable future. I want to encourage you to ultimately continue your great posts, have a nice weekend!
Hi, I desire to subscribe for this weblog to take most up-to-date updates, so where can i do it please assist.
Hi! I realize this is kind of off-topic but I had to ask. Does operating a well-established blog like yours take a massive amount work? I’m completely new to operating a blog but I do write in my diary daily. I’d like to start a blog so I will be able to share my experience and views online. Please let me know if you have any suggestions or tips for new aspiring bloggers. Appreciate it!
I am really loving the theme/design of your weblog. Do you ever run into any internet browser compatibility problems? A small number of my blog visitors have complained about my blog not operating correctly in Explorer but looks great in Chrome. Do you have any suggestions to help fix this issue?
Actually no matter if someone doesn’t understand then its up to other people that they will help, so here it occurs.
Hey there! This is my 1st comment here so I just wanted to give a quick shout out and tell you I truly enjoy reading through your articles. Can you suggest any other blogs/websites/forums that deal with the same subjects? Thanks!
you are in reality a good webmaster. The site loading velocity is incredible. It sort of feels that you are doing any unique trick. In addition, The contents are masterpiece. you have performed a fantastic activity in this topic!
Hi there it’s me, I am also visiting this site regularly, this web site is truly pleasant and the users are actually sharing nice thoughts.
I always spent my half an hour to read this website’s articles everyday along with a cup of coffee.
My spouse and I stumbled over here coming from a different website and thought I might check things out. I like what I see so now i’m following you. Look forward to exploring your web page for a second time.
Hey There. I found your blog using msn. This is a very well written article. I will be sure to bookmark it and come back to read more of your useful information. Thanks for the post. I will definitely comeback.
Its like you read my mind! You seem to understand so much approximately this, like you wrote the book in it or something. I think that you simply could do with some p.c. to drive the message house a bit, however other than that, this is fantastic blog. A great read. I’ll definitely be back.
Wow, this article is nice, my sister is analyzing these things, so I am going to let know her.
Heya this is somewhat of off topic but I was wondering if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding know-how so I wanted to get advice from someone with experience. Any help would be greatly appreciated!
Thanks for finally writing about > %blog_title% < Liked it!
Sweet blog! I found it while browsing on Yahoo News. Do you have any tips on how to get listed in Yahoo News? I’ve been trying for a while but I never seem to get there! Cheers
Исключительный мужской эротический массаж в Москве с джакузи
Fine way of describing, and nice post to take information concerning my presentation topic, which i am going to convey in university.
Appreciating the hard work you put into your website and in depth information you present. It’s great to come across a blog every once in a while that isn’t the same outdated rehashed material. Wonderful read! I’ve saved your site and I’m including your RSS feeds to my Google account.
When someone writes an article he/she keeps the thought of a user in his/her mind that how a user can know it. So that’s why this article is great. Thanks!
Thank you for the auspicious writeup. It if truth be told was a entertainment account it. Glance complex to far added agreeable from you! By the way, how can we keep in touch?
Simply want to say your article is as amazing. The clearness in your post is just spectacular and i could assume you are an expert on this subject. Fine with your permission let me to grab your feed to keep updated with forthcoming post. Thanks a million and please continue the gratifying work.
I really like what you guys are up too. This type of clever work and exposure! Keep up the amazing works guys I’ve incorporated you guys to our blogroll.
wonderful publish, very informative. I’m wondering why the other experts of this sector do not understand this. You should continue your writing. I am sure, you have a huge readers’ base already!
I want to to thank you for this good read!! I definitely enjoyed every little bit of it. I’ve got you bookmarked to check out new stuff you post
I read this article fully concerning the comparison of latest and preceding technologies, it’s awesome article.
Hi! I could have sworn I’ve been to this site before but after browsing through a few of the posts I realized it’s new to me. Nonetheless, I’m definitely pleased I discovered it and I’ll be bookmarking it and checking back regularly!
Very quickly this web site will be famous among all blogging viewers, due to it’s pleasant articles
Thanks for a marvelous posting! I truly enjoyed reading it, you will be a great author. I will always bookmark your blog and will eventually come back at some point. I want to encourage one to continue your great job, have a nice holiday weekend!
Keep on working, great job!
Hi there, I found your web site via Google whilst searching for a comparable topic, your web site got here up, it appears good. I have bookmarked it in my google bookmarks.
Fine way of explaining, and good piece of writing to take information concerning my presentation subject, which i am going to convey in academy.
I seriously love your blog.. Pleasant colors & theme. Did you create this site yourself? Please reply back as I’m planning to create my very own website and would like to know where you got this from or what the theme is called. Many thanks!
Hi there to every one, it’s in fact a good for me to visit this site, it consists of precious Information.
You really make it seem so easy with your presentation but I find this topic to be really something which I think I would never understand. It seems too complicated and very broad for me. I am looking forward for your next post, I will try to get the hang of it!
What’s up, yup this piece of writing is in fact nice and I have learned lot of things from it concerning blogging. thanks.
What’s up to all, how is all, I think every one is getting more from this website, and your views are nice for new viewers.
I got this site from my pal who told me about this website and now this time I am visiting this web site and reading very informative articles or reviews here.
It’s awesome to visit this site and reading the views of all friends about this piece of writing, while I am also eager of getting knowledge.
Woah! I’m really enjoying the template/theme of this site. It’s simple, yet effective. A lot of times it’s difficult to get that “perfect balance” between user friendliness and visual appearance. I must say you have done a awesome job with this. In addition, the blog loads very fast for me on Chrome. Exceptional Blog!
Great article, just what I wanted to find.
Wow, this article is pleasant, my sister is analyzing such things, so I am going to inform her.
Hiya! I know this is kinda off topic however , I’d figured I’d ask. Would you be interested in exchanging links or maybe guest writing a blog article or vice-versa? My website addresses a lot of the same subjects as yours and I feel we could greatly benefit from each other. If you are interested feel free to send me an e-mail. I look forward to hearing from you! Terrific blog by the way!
Dear immortals, I need some wow gold inspiration to create.
Have you ever considered about including a little bit more than just your articles? I mean, what you say is valuable and all. However think of if you added some great visuals or video clips to give your posts more, “pop”! Your content is excellent but with images and video clips, this website could certainly be one of the most beneficial in its niche. Good blog!
This article will help the internet people for creating new website or even a blog from start to end.
Hurrah! Finally I got a webpage from where I can in fact get useful data regarding my study and knowledge.
I’m not sure why but this web site is loading extremely slow for me. Is anyone else having this issue or is it a problem on my end? I’ll check back later and see if the problem still exists.
I do accept as true with all the concepts you have presented for your post. They are very convincing and will definitely work. Still, the posts are too brief for novices. May you please extend them a bit from next time? Thank you for the post.
Good respond in return of this issue with solid arguments and describing all regarding that.
Fantastic beat ! I wish to apprentice while you amend your site, how can i subscribe for a blog site? The account aided me a acceptable deal. I had been tiny bit acquainted of this your broadcast provided bright clear concept
Every weekend i used to go to see this website, because i want enjoyment, as this this site conations really good funny stuff too.
It’s in reality a nice and helpful piece of information. I’m satisfied that you shared this helpful info with us. Please stay us informed like this. Thanks for sharing.
Good info. Lucky me I ran across your site by accident (stumbleupon). I have book-marked it for later!
I’m not sure why but this blog is loading incredibly slow for me. Is anyone else having this issue or is it a problem on my end? I’ll check back later and see if the problem still exists.
I think this is one of the most important information for me. And i’m glad reading your article. But want to remark on few general things, The website style is perfect, the articles is really excellent : D. Good job, cheers
Aw, this was a very nice post. Spending some time and actual effort to create a very good article but what can I say I put things off a lot and never seem to get anything done.
Please let me know if you’re looking for a article writer for your weblog. You have some really great posts and I think I would be a good asset. If you ever want to take some of the load off, I’d absolutely love to write some material for your blog in exchange for a link back to mine. Please blast me an e-mail if interested. Cheers!
This is the right website for anyone who really wants to find out about this topic. You realize so much its almost hard to argue with you (not that I personally would want toHaHa). You definitely put a brand new spin on a topic that has been written about for years. Excellent stuff, just great!
Superb blog! Do you have any recommendations for aspiring writers? I’m planning to start my own website soon but I’m a little lost on everything. Would you suggest starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I’m totally confused .. Any ideas? Many thanks!
naturally like your website however you need to test the spelling on quite a few of your posts. Several of them are rife with spelling problems and I in finding it very bothersome to tell the truth on the other hand I will surely come back again.
I think this is one of the most important information for me. And i’m glad reading your article. But wanna remark on few general things, The website style is perfect, the articles is really nice : D. Good job, cheers
Thank you for the auspicious writeup. It in fact used to be a entertainment account it. Glance complex to far added agreeable from you! By the way, how can we keep up a correspondence?
It’s really a nice and helpful piece of information. I’m satisfied that you simply shared this helpful info with us. Please stay us informed like this. Thanks for sharing.
Appreciate the recommendation. Will try it out.
Thanks for sharing your thoughts on %meta_keyword%. Regards
Everything is very open with a very clear description of the issues. It was truly informative. Your website is extremely helpful. Thank you for sharing!
Great goods from you, man. I’ve be mindful your stuff prior to and you’re simply too wonderful. I really like what you’ve received here, really like what you’re stating and the way during which you assert it. You make it entertaining and you still take care of to stay it sensible. I can not wait to read far more from you. This is actually a great website.
Ищете надежного подрядчика для устройства стяжки пола в Москве? Обращайтесь к нам на сайт styazhka-pola24.ru! Мы предлагаем услуги по залитию стяжки пола любой сложности и площади, а также гарантируем быстрое и качественное выполнение работ.
строительное снабжение
I appreciate, lead to I found exactly what I used to be looking for. You have ended my 4 day long hunt! God Bless you man. Have a nice day. Bye
Механизированная штукатурка стен от mehanizirovannaya-shtukaturka-moscow.ru – это оптимальное сочетание цены, качества и скорости.
Hey there just wanted to give you a quick heads up. The text in your post seem to be running off the screen in Firefox. I’m not sure if this is a format issue or something to do with web browser compatibility but I thought I’d post to let you know. The layout look great though! Hope you get the problem resolved soon. Cheers
I enjoy what you guys are up too. Such clever work and coverage! Keep up the great works guys I’ve you guys to my blogroll.
I’ve read some just right stuff here. Definitely value bookmarking for revisiting. I wonder how so much attempt you put to create this kind of magnificent informative web site.
You really make it seem so easy with your presentation but I find this topic to be really something which I think I would never understand. It seems too complicated and very broad for me. I am looking forward for your next post, I will try to get the hang of it!
Hi there to every body, it’s my first pay a visit of this webpage; this weblog consists of awesome and truly fine stuff for readers.
Hi, I check your blogs like every week. Your writing style is awesome, keep doing what you’re doing!
Попробуйте механизированную штукатурку от mehanizirovannaya-shtukaturka-moscow.ru и убедитесь в ее эффективности. Ваш дом заслуживает лучшего!
Hi there, yup this piece of writing is in fact nice and I have learned lot of things from it about blogging. thanks.
Great post.
Excellent, what a webpage it is! This weblog gives useful information to us, keep it up.
Hello there! This post couldn’t be written any better! Looking at this post reminds me of my previous roommate! He constantly kept talking about this. I will forward this information to him. Pretty sure he will have a very good read. Many thanks for sharing!
Heya i’m for the primary time here. I came across this board and I find It truly useful & it helped me out a lot. I am hoping to provide something back and help others like you helped me.
Thank you for some other informative web site. Where else may just I am getting that kind of info written in such a perfect method? I have a challenge that I am simply now operating on, and I have been at the glance out for such information.
Wow, this article is pleasant, my sister is analyzing such things, thus I am going to tell her.
I believe what you postedwrotethink what you postedwrotesaidbelieve what you postedtypedsaidthink what you postedtypedWhat you postedtypedsaid was very logicala bunch of sense. But, what about this?think about this, what if you were to write a killer headlinetitle?content?typed a catchier title? I ain’t saying your content isn’t good.ain’t saying your content isn’t gooddon’t want to tell you how to run your blog, but what if you added a titleheadlinetitle that grabbed people’s attention?maybe get people’s attention?want more? I mean %BLOG_TITLE% is a little vanilla. You might look at Yahoo’s home page and see how they createwrite news headlines to get viewers interested. You might add a related video or a related pic or two to get readers interested about what you’ve written. Just my opinion, it could bring your postsblog a little livelier.
Hello! This is my first visit to your blog! We are a collection of volunteers and starting a new initiative in a community in the same niche. Your blog provided us valuable information to work on. You have done a marvellous job!
Hi, just wanted to say, I enjoyed this post. It was funny. Keep on posting!
Hmm it appears like your website ate my first comment (it was extremely long) so I guess I’ll just sum it up what I had written and say, I’m thoroughly enjoying your blog. I as well am an aspiring blog blogger but I’m still new to the whole thing. Do you have any suggestions for beginner blog writers? I’d certainly appreciate it.
Pretty! This was a really wonderful post. Thanks for providing this information.
I love your blog.. very nice colors & theme. Did you design this website yourself or did you hire someone to do it for you? Plz reply as I’m looking to design my own blog and would like to know where u got this from. appreciate it
We are a group of volunteers and starting a new scheme in our community. Your site provided us with valuable information to work on. You have done an impressive job and our whole community will be grateful to you.
Hi there! This post couldn’t be written any better! Reading this post reminds me of my good old room mate! He always kept talking about this. I will forward this page to him. Pretty sure he will have a good read. Thanks for sharing!
I am not certain the place you’re getting your information, however great topic. I needs to spend a while finding out much more or figuring out more. Thank you for magnificent info I was searching for this information for my mission.
Hello! This post couldn’t be written any better! Reading this post reminds me of my good old room mate! He always kept talking about this. I will forward this page to him. Pretty sure he will have a good read. Thank you for sharing!
Сделайте свой первый шаг к большому выигрышу с lucky jet онлайн! Веселье и возможности для заработка ждут вас после регистрации на 1win.
Everything is very open with a precise description of the issues. It was really informative. Your website is extremely helpful. Thank you for sharing!
Oh my goodness! Amazing article dude! Thank you, However I am going through difficulties with your RSS. I don’t know why I can’t subscribe to it. Is there anybody else getting identical RSS problems? Anyone who knows the solution will you kindly respond? Thanx!!
Hi, i feel that i saw you visited my weblog so i got here to go back the prefer?.I am trying to in finding things to improve my site!I assume its good enough to use some of your ideas!!
It is perfect time to make a few plans for the future and it is time to be happy. I have read this post and if I may just I wish to recommend you few fascinating things or advice. Perhaps you could write next articles referring to this article. I want to read more things approximately it!
Why users still use to read news papers when in this technological world everything is accessible on net?
Usually I do not read article on blogs, however I wish to say that this write-up very forced me to try and do so! Your writing taste has been amazed me. Thank you, quite great article.
Asking questions are truly pleasant thing if you are not understanding anything fully, except this post offers nice understanding even.
If you are going for most excellent contents like me, simply pay a visit this website daily as it offers quality contents, thanks
Hello, I think your website could be having internet browser compatibility issues. When I look at your web site in Safari, it looks fine however, if opening in IE, it has some overlapping issues. I just wanted to give you a quick heads up! Besides that, fantastic website!
Your style is very unique compared to other people I have read stuff from. Thank you for posting when you have the opportunity, Guess I will just bookmark this page.
Wow, marvelous blog layout! How long have you been blogging for? you make blogging look easy. The overall look of your web site is great, let alone the content!
I couldn’t resist commenting. Perfectly written!
Wow, marvelous blog layout! How long have you been blogging for? you make blogging look easy. The overall look of your site is fantastic, let alone the content!
Great article! We will be linking to this great article on our site. Keep up the good writing.
You’re so cool! I don’t think I’ve read something like this before. So good to find somebody with some original thoughts on this subject. Really.. thanks for starting this up. This site is something that’s needed on the web, someone with some originality!
I visit day-to-day some web pages and blogs to read articles, except this weblog provides quality based articles.
This is a good tip especially to those new to the blogosphere. Short but very accurate information Thanks for sharing this one. A must read article!
Thanks for ones marvelous posting! I genuinely enjoyed reading it, you are a great author.I will always bookmark your blog and will come back very soon. I want to encourage yourself to continue your great posts, have a nice holiday weekend!
I go to see day-to-day some websites and blogs to read articles or reviews, but this webpage offers quality based content.
My brother suggested I would possibly like this website. He used to be totally right. This submit actually made my day. You cann’t consider just how much time I had spent for this information! Thank you!
You’re so cool! I don’t suppose I’ve read something like this before. So nice to find somebody with some original thoughts on this issue. Really.. thank you for starting this up. This website is something that is needed on the web, someone with some originality!
I couldn’t resist commenting. Well written!
Your style is very unique compared to other people I have read stuff from. Many thanks for posting when you have the opportunity, Guess I will just bookmark this site.
I am sure this article has touched all the internet people, its really really pleasant post on building up new website.
You really make it seem so easy together with your presentation however I find this topic to be really something which I feel I would never understand. It sort of feels too complicated and very extensive for me. I am taking a look forward for your next submit, I will try to get the grasp of it!
What’s up Dear, are you really visiting this web site daily, if so after that you will definitely get pleasant knowledge.
Hurrah! At last I got a website from where I be able to really take helpful information regarding my study and knowledge.
What’s up, after reading this awesome article i am too happy to share my experience here with friends.
Ahaa, its good conversation concerning this article here at this blog, I have read all that, so now me also commenting here.
Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.
Highly energetic article, I liked that a lot. Will there be a part 2?
Really no matter if someone doesn’t understand then its up to other viewers that they will help, so here it occurs.
It is perfect time to make some plans for the future and it is time to be happy. I have read this post and if I could I wish to suggest you few interesting things or advice. Perhaps you could write next articles referring to this article. I want to read more things about it!
WOW just what I was searching for. Came here by searching for %keyword%
I’m not sure where you are getting your info, but good topic. I needs to spend some time learning more or understanding more. Thanks for magnificent information I was looking for this information for my mission.
I have recently started a web site, the information you provide on this site has helped me greatly. Thank you for all of your time & work.
I’ve read several just right stuff here. Definitely value bookmarking for revisiting. I wonder how so much attempt you set to create such a great informative site.
Good info. Lucky me I discovered your site by accident (stumbleupon). I have bookmarked it for later!
Great post.
I am extremely inspired with your writing skills and alsosmartly as with the format for your blog. Is this a paid subject or did you customize it yourself? Either way stay up the nice quality writing, it’s rare to peer a nice blog like this one nowadays..
Hello, I check your new stuff regularly. Your story-telling style is awesome, keep up the good work!
Nice post. I was checking continuously this blog and I’m impressed! Very helpful information specifically the last part 🙂 I care for such info much. I was seeking this particular information for a very long time. Thank you and best of luck.
I all the time emailed this website post page to all my associates, because if like to read it then my links will too.
Way cool! Some very valid points! I appreciate you writing this post and the rest of the site is very good.
Together with almost everything that appears to be developing within this specific subject matter, your opinions are actually very stimulating. On the other hand, I appologize, but I do not subscribe to your entire idea, all be it exciting none the less. It looks to everybody that your opinions are generally not totally validated and in fact you are your self not even thoroughly confident of your point. In any event I did enjoy reading it.
Hi, I think your blog might be having browser compatibility issues. When I look at your website in Firefox, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, superb blog!
Some genuinely select content on this internet site, saved to fav.
Thanks for this post, I am a big fan of this site would like to proceed updated.
I have recently started a website, the information you provide on this web site has helped me greatly. Thank you for all of your time & work. “My dear and old country, here we are once again together faced with a heavy trial.” by Charles De Gaulle.
What Is Puravive? Before we delve into the various facets of the supplement, let’s start with the most important
Lottery Defeater Software? Lottery Defeater is a software application created to help people win lotteries
What Is Sugar Defender? Sugar Defender Drops is a powerful friend for people who want to control their blood sugar levels
Excellent site you have here but I was curious about if you knew of any community forums that cover the same topics talked about in this article? I’d really like to be a part of group where I can get suggestions from other knowledgeable individuals that share the same interest. If you have any suggestions, please let me know. Kudos!
hey there and thank you for your info – I have definitely picked up something new from right here. I did however expertise several technical points using this site, as I experienced to reload the web site a lot of times previous to I could get it to load correctly. I had been wondering if your hosting is OK? Not that I am complaining, but sluggish loading instances times will often affect your placement in google and can damage your high-quality score if ads and marketing with Adwords. Anyway I’m adding this RSS to my email and could look out for much more of your respective interesting content. Ensure that you update this again soon..
I really like your blog.. very nice colors & theme. Did you create this website yourself or did you hire someone to do it for you? Plz respond as I’m looking to create my own blog and would like to find out where u got this from. thanks a lot
Fantastic website you have here but I was curious if you knew of any message boards that cover the same topics talked about in this article? I’d really love to be a part of online community where I can get advice from other knowledgeable individuals that share the same interest. If you have any recommendations, please let me know. Thank you!
Hi, Neat post. There is a problem with your web site in internet explorer, would check this… IE still is the market leader and a large portion of people will miss your great writing because of this problem.
I’m impressed, I have to say. Really hardly ever do I encounter a weblog that’s each educative and entertaining, and let me let you know, you will have hit the nail on the head. Your concept is excellent; the problem is one thing that not enough persons are speaking intelligently about. I’m very completely happy that I stumbled across this in my search for one thing regarding this.
Balmorex Pro is a natural and amazing pain relief formula that decreases joint pain and provides nerve compression relief.
Having read this I thought it was very informative. I appreciate you taking the time and effort to put this article together. I once again find myself spending way to much time both reading and commenting. But so what, it was still worth it!
Once I originally commented I clicked the -Notify me when new feedback are added- checkbox and now every time a remark is added I get four emails with the same comment. Is there any means you can take away me from that service? Thanks!
Hi, I think your site might be having browser compatibility issues. When I look at your website in Safari, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, fantastic blog!
Saved as a favorite, I really like your blog!
I visited a lot of website but I believe this one holds something extra in it in it
Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.
You have remarked very interesting points! ps nice site. “We simply rob ourselves when we make presents to the dead.” by Publilius Syrus.
This web site is mostly a walk-by for the entire information you wanted about this and didn’t know who to ask. Glimpse here, and you’ll undoubtedly discover it.
Great write-up, I am normal visitor of one?¦s website, maintain up the excellent operate, and It is going to be a regular visitor for a long time.
Unquestionably believe that which you stated. Your favorite justification appeared to be on the internet the simplest thing to be aware of. I say to you, I definitely get irked while people consider worries that they plainly do not know about. You managed to hit the nail upon the top as well as defined out the whole thing without having side effect , people can take a signal. Will likely be back to get more. Thanks
Hello my friend! I want to say that this post is amazing, nice written and come with almost all significant infos. I’d like to look extra posts like this .
I’ve been absent for a while, but now I remember why I used to love this web site. Thank you, I will try and check back more frequently. How frequently you update your website?
These are truly enormous ideas in about blogging. You have touched some pleasant factors here. Any way keep up wrinting.
The subsequent time I learn a blog, I hope that it doesnt disappoint me as much as this one. I imply, I do know it was my option to learn, but I really thought youd have one thing attention-grabbing to say. All I hear is a bunch of whining about something that you might repair should you werent too busy in search of attention.
Hey, you used to write magnificent, but the last several posts have been kinda boringK I miss your super writings. Past few posts are just a little out of track! come on!
all the time i used to read smaller articles which also clear their motive, and that is also happening with this post which I am reading at this place.
This is the right web site for anybody who wishes to find out about this topic. You understand so much its almost hard to argue with you (not that I personally would want toHaHa). You definitely put a brand new spin on a topic that’s been written about for years. Great stuff, just excellent!
This is the right blog for anyone who wants to find out about this topic. You realize so much its almost hard to argue with you (not that I actually would want…HaHa). You definitely put a new spin on a topic thats been written about for years. Great stuff, just great!
That is very fascinating, You are an overly skilled blogger. I’ve joined your rss feed and look ahead to in the hunt for extra of your excellent post. Also, I’ve shared your website in my social networks!
Excellent post. I was checking continuously this blog and I am impressed! Very useful information specially the last part 🙂 I care for such info a lot. I was seeking this particular info for a long time. Thank you and good luck.
It’s going to be end of mine day, but before end I am reading this enormous article to increase my experience.
Hello there! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me. Anyhow, I’m definitely glad I found it and I’ll be bookmarking and checking back frequently!
F*ckin’ tremendous things here. I am very glad to see your post. Thanks a lot and i’m looking forward to contact you. Will you kindly drop me a mail?
I like your writing style truly loving this web site.
I like this web blog its a master peace ! Glad I found this on google .
Thanks for finally writing about > %blog_title% < Liked it!
The other day, while I was at work, my sister stole my iPad and tested to see if it can survive a 25 foot drop, just so she can be a youtube sensation. My iPad is now broken and she has 83 views. I know this is completely off topic but I had to share it with someone!
I am not rattling fantastic with English but I find this rattling easygoing to understand.
I for all time emailed this website post page to all my friends, as if like to read it after that my links will too.
Hey there! This post couldn’t be written any better! Reading through this post reminds me of my good old room mate! He always kept talking about this. I will forward this post to him. Fairly certain he will have a good read. Thank you for sharing!
Франшиза автомойки – отличное решение для начинающих бизнесменов. Мы предлагаем проверенную модель и постоянную поддержку.
I went over this website and I conceive you have a lot of wonderful info, saved to my bookmarks (:.
Woah! I’m really loving the template/theme of this website. It’s simple, yet effective. A lot of times it’s very difficult to get that “perfect balance” between user friendliness and visual appeal. I must say you have done a very good job with this. In addition, the blog loads extremely fast for me on Safari. Exceptional Blog!
Well I sincerely liked studying it. This tip provided by you is very helpful for correct planning.
Thank you for the sensible critique. Me and my neighbor were just preparing to do a little research on this. We got a grab a book from our local library but I think I learned more from this post. I am very glad to see such fantastic information being shared freely out there.
Howdy would you mind sharing which blog platform you’re using? I’m going to start my own blog in the near future but I’m having a tough time making a decision between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something completely unique. P.S My apologies for being off-topic but I had to ask!
Very interesting subject, appreciate it for putting up. “Wrinkles should merely indicate where smiles have been.” by Mark Twain.
Great line up. We will be linking to this great article on our site. Keep up the good writing.
I conceive this web site contains some very great information for everyone : D.
I do love the way you have framed this situation plus it really does supply me a lot of fodder for consideration. On the other hand, through everything that I have experienced, I just simply trust when the feed-back pack on that folks keep on point and don’t get started upon a soap box involving the news du jour. All the same, thank you for this fantastic piece and even though I do not necessarily concur with it in totality, I regard your point of view.
Master the game and claim your place among the elite. Hawkplay
I just could not depart your website prior to suggesting that I extremely enjoyed the standard information a person provide for your visitors? Is gonna be back often in order to check up on new posts
I discovered your weblog website on google and examine a couple of of your early posts. Continue to keep up the excellent operate. I simply further up your RSS feed to my MSN News Reader. In search of ahead to studying more from you afterward!…
What i don’t understood is actually how you are not really much more well-liked than you might be right now. You’re very intelligent. You realize therefore considerably relating to this subject, produced me personally consider it from so many varied angles. Its like men and women aren’t fascinated unless it is one thing to accomplish with Lady gaga! Your own stuffs great. Always maintain it up!
Great line up. We will be linking to this great article on our site. Keep up the good writing.
hi!,I love your writing so much! proportion we keep in touch more approximately your post on AOL? I need an expert in this space to solve my problem. May be that is you! Taking a look forward to peer you.
Some truly nice and utilitarian info on this site, as well I think the layout has good features.
Hello there, I found your web site via Google while searching for a related topic, your site came up, it looks good. I have bookmarked it in my google bookmarks.
This is very interesting, You are an excessively professional blogger. I have joined your feed and sit up for in search of more of your magnificent post. Also, I have shared your web site in my social networks
Sight Care
Fit spresso
Cellucare review
Lottery defeater software review
Wohh exactly what I was searching for, regards for posting.
Sight care review
Fitspresso
Sightcare reviews
Lottery defeater software
Lottery defeater software reviews
Opinipix
Weight loss juice
Fitspresso review
Fitspresso
Fitspresso
Dentavim reviews
Fitspresso review
Fitspresso review
Fitspresso review
Fitspresso review
Fitspresso review
Fitspresso reviews
hey there and thank you for your info – I have certainly picked up something new from right here. I did however expertise a few technical issues using this website, as I experienced to reload the web site lots of times previous to I could get it to load properly. I had been wondering if your web host is OK? Not that I’m complaining, but sluggish loading instances times will very frequently affect your placement in google and could damage your high quality score if ads and marketing with Adwords. Anyway I am adding this RSS to my email and can look out for a lot more of your respective intriguing content. Make sure you update this again very soon..
Juice to loss weight
Hey! Do you know if they make any plugins to safeguard against hackers? I’m kinda paranoid about losing everything I’ve worked hard on. Any suggestions?
Zencortex reviews
Lottery defeater reviews
Neotonics review
Sight Care reviews
Dentavim review
I’m typically to blogging and i actually admire your content. The article has actually peaks my interest. I’m going to bookmark your web site and hold checking for new information.
Lottery defeater
I am not sure where you are getting your info, but good topic. I needs to spend some time learning more or understanding more. Thanks for wonderful info I was looking for this info for my mission.
Sight Care
Pineal XT reviews
Fitspresso is a brand-new natural weight loss aid designed to work on the root cause of excess and unexplained weight gain. The supplement uses an advanced blend of vitamins, minerals, and antioxidants to support healthy weight loss by targeting the fat cells’ circadian rhythm
I appreciate, cause I found just what I was looking for. You have ended my four day long hunt! God Bless you man. Have a great day. Bye
Kerassentials
Thanks for your marvelous posting! I quite enjoyed reading it, you will be a great author.I will make certain to bookmark your blog and will come back from now on. I want to encourage yourself to continue your great work, have a nice evening!
Fitspresso review
Keep functioning ,splendid job!
TONIC GREENS REVIEW
Customize your character and get ready for battle—join today Lodibet
LOTTERY DEFEATER
Hurray, this is just the right information that I needed. You make me want to learn more! Stop by my page QH5 about Thai-Massage.
Nice
BOOSTARO REVIEWS
BOOSTER XT
MITOLYN